为了翻拍影史经典《狂蟒之灾》，格里夫（保罗·路德 饰）和道格（杰克·布莱克 饰）成立史上最穷剧组！在唯一一条演员蛇因伤下线后，他们决定深入亚马逊雨林捉蛇补位，却意外遇上真巨蟒，原本滑稽混乱的片场瞬间沦为致命险境。在蛇口之下四处逃窜的他们，最终是会全员殒命还是顺利杀青？
影片讲述了一场震惊全国的特大运钞车抢劫案发生后，嫌疑人小宝在无现场犯罪证明情况下金蝉脱壳，然而犯罪的种子已然在心中生根发芽，伴随着时间野蛮生长，终将在警方的明察秋毫中爆裂迸发……
Based on the novel by Karel Capek, the prominent Czech writer of the early 20th century who coined the word robot for his play R.U.R., the story revolves around a discovery of Krakatit - a powerful explosive - by Prokop, an experimental scientist who, following an accidental explosion in his lab, slips in and out of delirium. When he realises that, in a delirious period, he has given the formula for making Krakatit to one of his colleagues, he tries to find the man, who does not realize how dangerous a thing Krakatit is. In the process, he nearly gives his discovery away again to foreign interests, a group of anarchists, and even greater forces of darkness...
